Drug Delivery and Stability

S. Tongiani, D. Vander Velde, T. Ozeki, and V. J. Stella, “Sulfoalkyl Ether-Alkyl Ether Cyclodextrin Derivatives:  Their Synthesis, NMR Characterization and Binding of 6α-Methylprednisolone,” J. Pharm. Sci., 94, 2380-2392 (2005).

B. M. Liederer, T. Fuchs, D. Vander Velde, T. J. Siahaan, and R. T. Borchardt, “Effects of Amino Acid Chirality and the Chemical Linker on the Cell Permeation Characteristics of Cyclic Prodrugs of Opioid Peptides,” J. Med. Chem., 49, 1261-1270 (2006).

S. L. Krogmeier, D. S. Reddy, D. Vander Velde, G. H. Lushington, T. J. Siahaan, C. R. Middaugh, R. T. Borchardt, and E. M. Topp, “Deamidation of Model β-Turn Cyclic Peptides in the Solid State,” J. Pharm. Sci., 94, 2616-2631 (2005).

A. Safavy, G. I. Georg, D. Vander Velde, K. P. Raisch, K. Safavy, J. A. Bonner, M. B. Khazaeli, and D. J. Buchsbaum, “Site-specifically traced drug release and biodistribution of a paclitaxel-antibody conjugate toward improvement of the linker structure,” Bioconjugate Chem., 15, 1264-1274 (2005).
B. Li, R. T. Borchardt, E. M. Topp, D. Vander Velde, and R. L. Schowen, “Racemization of an Asparagine Residue During Peptide Deamidation,” J. Am. Chem. Soc., 125, 10152-10153 (2003).

 H. Ouyang, D.G. Vander Velde, R T. Borchardt, and T.J. Siahaan, “Synthesis and conformational analysis of a coumarinic acid-based cyclic prodrug of an opioid peptide with modified sensitivity to esterase-catalyzed bioconversion,” J. Peptide Res., 59, 183-195 (2002).

C. Ampasavate, G. A. Chandorkar, D. G. Vander Velde, J. F. Stobaugh, and K. L. Audus, “Transport and metabolism of opioid peptides across BeWocells, an in vitro model of the placental barrier,” Int. J. Pharmaceutics, 233, 85-98 (2002).

M. Chittchang, N. Salamat-Miller, H. H. Alur, D. Vander Velde, A. K. Mitra and T. P. Johnston, “Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and microporous membrane transport, Part II : Diffusion Studies,” J. Pharm. Pharmacol., 54, 1491-1496 (2002).

J. Gao, S. L. Winslow, D. Vander Velde, J. Aubé, and R. T. Borchardt, “Transport Characteristics of Peptides and Peptidomimetics: 2. Hydroxyethylamine Bioisostere-Containing Peptidomimetics as Substrates for the Oligopeptide Transporter and P-Glycoprotein in the Intestinal Mucosa,” J. Peptide Research, 57, 316-329 (2001).

A. S. Antipas, D. G. Vander Velde, S. D. S. Jois, T. J. Siahaan, and V. J. Stella, "Effect of Conformation on the Rate of Deamidation of Vancomycin in Aqueous Solutions," J. Pharm. Sci., 89, 742-750 (2000).

P. Jarho, D. Vander Velde, and V. J. Stella, "Cyclodextrin-Catalyzed Deacetylation of Spironolactone is pH and Cyclodextrin Dependent," J. Pharm. Sci., 89, 241-249 (2000).

D. Q. Ma, R. A. Rajewski, D. Vander Velde, and V. J. Stella, "Comparative Effects of SBE-ß-CD and HP-ß-CD on the Stability of Two Anti-Neoplastic Agents, Melphalan and Carnitine," J. Pharm. Sci., 89, 275-287 (2000).

O. S. Gudmonsson, D. G. Vander Velde, S. D. S. Jois, A. Bak, T. J. Siahaan, and R. T. Borchardt,"The Effect of Conformation of the AcyloxyalkoxyBased Cyclic Prodrugs of Opioid Peptides on the Membrane Permeability," J. Peptide Research, 53, 403-413 (1999).

O. S. Gudmonsson, S. D. S. Jois, D. G. Vander Velde, T. J. Siahaan, B. Wang, and R. T.Borchardt,"The Effect of Conformation on the Membrane Permeation of Coumarinic Acid and Phenylproprionic AcidBased Cyclic Prodrugs of Opioid Peptides," J. Peptide Research, 53, 383-392 (1999).

E. A. Luna, D. Vander Velde, R. J. Tait, D. O. Thompson, R. A. Rajewski, and V. J. Stella, “Isolation and Magnetic Resonance Characterization of Monosubstituted Sulfobutyl Ether ß-Cyclodextrins,” J. Carbohydrate Res., 299, 111-118 (1997).