The Mass Spectrometry and Analytical Proteomics Laboratory
(MSL/APL). (Director Todd D. Williams www.msg.ku.edu/mass/index.shtml
and http://apl.ku.edu/ ) is a research resource with
a primary mission to provide collaboration and service
in chemical analysis by mass spectrometry and to educate
investigators on the uses of mass spectrometry as
a research tool.
The lab operates nine instruments
in two locations, Malott Hall and the Structural Biology
Center. Access to the resource varies from “walk up
and run your own sample” to the lab’s supervision
of graduate student or postdoctoral associates in
the facility working on extended projects. Instrumentation
covers most of the common ionization methods and data
acquisition in high resolution and/or tandem MS modes
on the facility TOF, TOF/TOF, triple quadrupoles,
Q-TOF or hybrid linear ion trap ICR instrument (LTQ-FT).
A suite of separation interfaces are supported including
GC and HPLC in the performance regimes of analytical
micro, capillary, nano and ultrahigh pressure. Laboratory
personnel are available at all times to discuss the
capabilities of the laboratory, to offer advice on
experimental design and to discuss the interpretation
of data. Investigators are routinely trained to use
primary data presentation software to interrogate
their experiments. The APL maintains a collection
of software tools for the analysis of proteomics experiments.
The lab has experience with a wide variety of sample
types including, providing support to synthetic groups,
characterizing medicinal compounds and natural products,
and characterizing proteins and protein modifications.
The services of the laboratory are typically used
by the School of Pharmacy and the Departments of Medicinal
Chemistry and Chemistry, but any investigator considering
mass spectrometry for problem solving is encouraged
to contact the Director.
