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Photo: Doug Koch, KU University Relations

The Mass Spectrometry Laboratory (MSL) is a research resource with a primary mission to provide service in chemical analysis by mass spectrometry to research workers in the University and to educate investigation on the uses of mass spectrometry as a research tool. Laboratory personnel are always available to discuss the capabilities of the laboratory, provide advise on what method should be used and discuss the interpretation of results. The MSL is part of the Molecular Structures Group, a campus wide consortium made up of the NMR, MSL, X-ray Crystallography, and Molecular Graphics and Modeling laboratories.

The Mass Spectrometry Laboratory is routinely utilized by a number of departments including: Chemistry, Medicinal Chemistry, Molecular Biosciences and Pharmaceutical Chemistry. The lab serves a wide variety of roles from support of small molecule synthesis to analysis of whole proteins isolated from organisms.

The lab operates six instruments: two Nermag quadrupoles, a VG ZAB high-resolution double-focusing instrument, and a VG Autospec-Q tandem hybrid of EBEqQ configuration. The lab recently installed a dedicated HPLC/MS instrument with a triple quadrupole analyzer (Micromass Ultima) and another high performance tandem instrument of quadrupole-time of flight configuration (Micromass Q-TOF2). The MSL collaborates with the Biochemical Research Service Laboratory in utilizing a high resolution MALDI-TOF instrument.

The laboratory can usually generate routine low-resolution spectra by electron ionization (EI), chemical ionization (CI), fast atom bombardment (FAB) or Electrospray (ESO) of organic compounds within days of submission. The lab routinely conducts exact mass determinations, tandem (MS/MS) experiments and HPLC separations with MS detection as required by investigators.

MSL Home Page

MSL Contact Information

MSL Staff

MSL Sample Submission Form

MSL Lab Rates

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Please send questions or comments concerning this Web site to Monique D. Pilch.